A Solvent-free Synthesis of Polyhydroquinolines via Hantzsch Multicomponent Condensation Catalyzed by Nanomagnetic-supported Sulfonic Acid

  • S Otokesh
  • N Koukabi
  • E Kolvari
  • A Amoozadeh
  • M Malmir
  • S Azhari
Keywords: Nanomagnetic-supported sulfonic acid, multicomponent reaction, solvent-free conditions, heterocyclic compound, Hantzsch reaction.

Abstract

A simple and efficient procedure for the synthesis of polyhydroquinolines was developed, involving a one-pot four-component Hantzsch condensation of aromatic aldehydes, 1,3-cyclohexanediones, alkyl acetoacetate and ammonium acetate in the presence of a catalytic amount of nanomagnetic-supported sulfonic acid under solvent-free conditions. The method offers several advantages including high yields, short reaction times, a simple work-up procedure and catalyst reusability for several runs. Furthermore, easy isolation of the catalyst from the reaction mixture was enabled by use of an external magnet.

KEYWORDS Nanomagnetic-supported sulfonic acid, multicomponent reaction, solvent-free conditions, heterocyclic compound, Hantzsch reaction.

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eISSN: 0379-4350