Synthesis of the Antimycobacterial Naphthoquinone, 7-Methyljuglone and its Dimer, Neodiospyrin

  • F van der Kooy
  • JJM Meyer
Keywords: 7-Methyljuglone, Friedel-Crafts acylation, neodiospyrin, antimycobacterial.

Abstract

We report on the laboratory-scale synthesis of the antimycobacterial naphthoquinone, 7-methyljuglone (7-methyl-5-hydroxy- 1,4-naphthoquinone) in a one step Friedel-Crafts acylation reaction. This compound was used to synthesize neodiospyrin, which possesses similar bioactivity.

KEYWORDS: 7-Methyljuglone; Friedel-Crafts acylation; neodiospyrin; antimycobacterial.

Published
2015-09-30
Section
Articles

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eISSN: 0379-4350