Synthesis and Antibacterial Activity of 1,3,4-Oxadiazole and 1,2,4-Triazole Derivatives of Salicylic Acid and its Synthetic Intermediates
Eight compounds 2–9 have been synthesized starting from salicylic acid, two of them (7 and 9) are novel. The four final products namely: 5-(2-hydroxy phenyl)-1,3,4-oxadiazole-2-thione 4, 3-(2-hydroxy phenyl)-1H-1,2,4-triazole-5-thiol 6, 3-(2-hydroxy phenyl)-4-amino-1,2,4-triazole-5-thiol 8 and 3-(2-hydroxy phenyl)-1-amino-1,2,4-triazole-5-thiol 9 have been prepared using known reactions. The structures of intermediates and final products were determined by spectroscopic IR, UV, 1H-NMR & MS-methods in addition to elemental analysis. Antibacterial activities of compounds 1–6 and 8 were investigated in vitro against Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa and the results are reported herein.
KEYWORDS: 1,3,4-Oxadiazole-2-thione; 1H-1,2,4-triazole-5-thiol; 4-amino-1,2,4-triazole-5-thiol; salicylic acid; antibacterial activity.
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