Synthesis of Dinaphtho-dioxaphosphocin-8-oxides, Epoxides and Bisphosphonates

  • M Kasthuraiah
  • AUR Sankar
  • BS Kumar
  • CS Reddy
  • CN Raju
Keywords: Dioxaphosphocin 8-oxides, dioxaphosphocin bisphosphonates, antimicrobial activity.

Abstract

Preparation of 8-substituted-16H-dinaphtho [2,1-d:1’,2’-g] [1,3,2] dioxaphosphocin 8-oxides (5a–g) with an eight-membered phosphorus heterocyclic system (2) and their epoxides and bisphosphonates was accomplished by reacting 8-bromo-dinaphthophosphocin (2) with different mono and bis Grignard reagents (3a–g and 6) followed by oxidation with H2O2. Their structures were confirmed by elemental and spectral (1H, 13C and 31P NMR) data analysis. Some of these compounds are found to possess moderate antimicrobial activity.

KEYWORDS: Dioxaphosphocin 8-oxides, dioxaphosphocin bisphosphonates, antimicrobial activity.

Published
2015-10-06
Section
Articles

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eISSN: 0379-4350