Synthesis and Antioxidant Activity of 3,3’-Diselanediylbis (N,N-Disubstituted Indolizine-1-carboxamide) and Derivatives
Aseries of novel diselenides 5a–e were synthesized from-haloketones, α-picoline alkenes and various secondary amines under a dry nitrogen atmosphere. The structures of these compounds were established by means of their spectral data and they were screened for scavenging activity against 1,1-diphenyl-2-picryl-hydrazyl (DPPH.). The results of this research showed that two of these compounds (5e and 5d) exhibited reasonable antioxidant activity. The intermediate, methyl 5-methylindolizine-1- carboxylate was prepared by condensation of methyl acrylate with 1-(carboxymethyl)-2-methylpyridinium halide, which was prepared from α-picoline and chloroacetic acid by using the Tschischibabin reaction.
Keywords: Antioxidants, diselenides, indolizine, free radical scavenger, 1,1-DPPH.
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