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South African Journal of Chemistry

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The Synthesis of Substituted Piperazine-cholesterol Conjugates for use as Components of Nucleic Acid Transfection Lipoplexes

R Ul Islam, MM Johnson, R Mohammed, J Hean, P Arbuthnot, CB de Koning, WAL van Otterlo

Abstract


A small library of cholesterol-piperazine conjugates were synthesized by the reaction of cholesteryl chloroformate with a set of substituted piperazines in dichloromethane at room temperature. The conjugates, all obtained in good to excellent yields, were synthesized to be key components of nucleic acid transfection lipoplexes.

Keywords: Piperazine, Cholesterol, Conjugates, Transfection, Cationic Lipoplexes




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