The Synthesis of Substituted Piperazine-cholesterol Conjugates for use as Components of Nucleic Acid Transfection Lipoplexes

  • R Ul Islam
  • MM Johnson
  • R Mohammed
  • J Hean
  • P Arbuthnot
  • CB de Koning
  • WAL van Otterlo
Keywords: Piperazine, Cholesterol, Conjugates, Transfection, Cationic Lipoplexes

Abstract

A small library of cholesterol-piperazine conjugates were synthesized by the reaction of cholesteryl chloroformate with a set of substituted piperazines in dichloromethane at room temperature. The conjugates, all obtained in good to excellent yields, were synthesized to be key components of nucleic acid transfection lipoplexes.

Keywords: Piperazine, Cholesterol, Conjugates, Transfection, Cationic Lipoplexes

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eISSN: 0379-4350