Expedient Access to an N-phenylpyrrolidin-2-yl Heterocycle via a Base-Induced Intramolecular aza-Michael Reaction

  • AJ Ferreira Ramos
  • TJ Nagem
  • JG Taylor
Keywords: aza Michael, intramolecular, catalysed, piperidine, pyrrolidine, base

Abstract

Ethyl 2-(1-phenylpiperidin-2-yl) acetate was formed in a spontaneous cyclization from (E)-ethyl 7-oxohept-2-enoate whereas ethyl [1-(2-bromophenyl)-2-pyrrolidinyl] acetate could be synthesized in good overall yield when employing a stoichiometric amount of base to facilitate the intramolecular aza-Michael reaction.

Keywords: aza Michael, intramolecular, catalysed, piperidine, pyrrolidine, base

Published
2015-10-13
Section
Articles

Journal Identifiers


eISSN: 0379-4350