Synthesis and Antibacterial Activity of some 5,5’-(1,4-phenylene)-bis-1,3,4-Oxadiazole and bis-1,2,4-Triazole Derivatives as Precursors of New S-Nucleosides

  • Y Datoussaid
  • A Othman
  • G Kirsch
Keywords: Terephthalic acid, 1, 3, 4-oxadiazole, 1H-1, 2, 4-triazole, S-nucleosides, antimicrobial activity


Five compounds, namely 5,5’-benzene-1,4-diylbis(1,3,4-oxadiazole-2-thiol)6 and 5,5’-benzene-1,4-diylbis(1H-1,2,4-triazole-3-thiol) 7a and its derivatives 7b–d were synthesized. Two related S-nucleosides 9 and 10 have been prepared from 6 and 7a. Some of these synthesized compounds were tested in vitro by spotting on Mueller Hinton Agar medium against some Gram-positive bacteria, Staphylococcus aureus and Enterococcus faecalis and three Gram-negative bacteria Escherichia coli, Pseudomonas aeruginosaPseudomonas fluorescens and compared with the known antibiotics cephalosporin (cefotaxim) and gentamycin. Compound 6 showed significant inhibitory activity against Gram-positive E. faecalis and Gram-negative E. coli bacteria while the others have shown variable inhibition activity.

Keywords: Terephthalic acid, 1,3,4-oxadiazole, 1H-1,2,4-triazole, S-nucleosides, antimicrobial activity


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eISSN: 0379-4350