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Re-screening and preliminary <i>in vitro</i> evaluation of resorcinol based Hsp90 inhibitors for potential protocidal activity

Théoneste Umumararungu
Michelle Isaacs
Heinrich C. Hoppe
Eleonora D. Goosen
Setshaba D. Khanye


This study explored a series of resorcinol derivatives originally identified as heat shock protein 90 inhibitors for activity against protozoan parasites. The repurposing of this series revealed that some of these compounds are active against chloroquine-sensitive Plasmodium falciparum (3D7) and Trypanosoma brucei brucei strains with IC50 values below 10 μM without obvious cytotoxic effects against human cervix adenocarcinoma (HeLa) cells at 25 μM.

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eISSN: 1996-840X
print ISSN: 0379-4350