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Tropical Journal of Pharmaceutical Research

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Myricetin promotes peripheral nerve regeneration in rat model of sciatic nerve injury via regulation of BDNFAkt/ GSK-3β/mTOR signalling pathway

Dechou Zhang, Jianhua Ge, Lisha Ye, Hongmei Tang, Xue Bai

Abstract


Purpose: To investigate the effects of myricetin on peripheral nerve regeneration in sciatic nerve crush injury model.

Methods: Separate groups of rats were administered myricetin at 25, 50 or 100 mg/kg body weight/day for 2 weeks. Functional recovery following sciatic nerve injury was assessed by foot position and walking track analyses, measurement of mechanical hyperalgesia, and withdrawal reflex latency (WRL).

Results: Myricetin treatment resulted in significantly enhanced recovery of sensorimotor functions as evidenced by increased scores in functional analysis tests. Myricetin treatment remarkably elevated brain derived neurotrophic factor (BDNF) expression, and also enhanced activation of Akt and mTORc1, reflecting up-regulation of PI3K/Akt/mTORC1 signalling involved in nerve regeneration.

Conclusion: Myricetin enhances functional recovery and nerve regeneration in rats. These findings suggest that myricetin is a potent neuroprotective agent with potential for the management of peripheral nerve injury.

Keywords: Glycogen synthase kinase 3β, Mammalian target of rapamycin (mTOR), Myricetin, Nerve regeneration



http://dx.doi.org/10.4314/tjpr.v17i12.6
AJOL African Journals Online