Antibacterial activities of constituents from Isolona cauliflora and Cleistochlamys kirkii

  • AC Odebode Department of Botany, University of Dar es Salaam, P.O. Box 35060 Dar es Salaam, Tanzania
  • SJM Mdachi Department of Chemistry, University of Dar es Salaam, P.O. Box 35061 Dar es Salaam, Tanzania
  • CC Joseph Department of Chemistry, University of Dar es Salaam, P.O. Box 35061 Dar es Salaam, Tanzania
  • BN Irungu Department of Chemistry, University of Dar es Salaam, P.O. Box 35061 Dar es Salaam, Tanzania

Abstract

Antibacterial activities of caulindole D, a mixture of caulindole E and F, pinocembrin and an oxyheptanoid (cleistenolide), obtained from stem barks of Isolona cauliflora and Cleistochlamys kirkii, on Staphylococcus aureus and Pseudomonas phaseolicola were determined. An in vitro assay test by paper disc method showed that the caulindole D, E and F from Isolona cauliflora produced no inhibition zone on both bacteria pathogens at 100-200 ppm while cleistochlamic acid from C. kirkii showed weak to moderate inhibition zone at 100-200 ppm. At concentration above 200 ppm, the bacteria pathogens were inhibited by all the compounds isolated from the plant extracts. Furthermore, there was an influence of bioassay method on the sensitivity of extracts on both test bacteria.

Tanz. J. Sci. Vol.29(2) 2003: 19-26
Published
2004-10-13
Section
Articles

Journal Identifiers


eISSN: 2507-7961
print ISSN: 0856-1761