Peliminary examination of herbal extracts on the inhibition of Helicobacter Pylori
Background: This work aims at describing the traditional uses, to determine the antimicrobial potential of two different extracts hexane, acetone of the leaves of Citrus unshiu, Citrus sinensis, Citrus limon, Laurus nobilis, Citrus paradisi on clinical strain of H. pylori in a bid to identify potential sources of cheap starting materials for the synthesis of new drugs. H. pylori strain was a culture collection of Hacettepe University, Turkey.
Methods: The activity was quantitatively assessed on the basis of the inhibition zone, and their activity index was also calculated along with the MIC method.
Results: All the plants demonstrated antimicrobial activity against H. pylori with zone of inhibition diameters ranging from 0 - 30 mm and minimum inhibitory concentration (MIC) values ranging from 1:512- 1:4096 dilutions.
Conclusion: The results may serve as scientific validation of the ethnomedicinal uses of the Citrus unshiu, Citrus sinensis, Citrus limon, Laurus nobilis, and Citrus paradisi in the treatment of H. pylori-related infections. However, further investigations would be necessary to determine their toxicological properties, in-vivo potencies and mechanism of action against H. pylori.
Key words: Helicobacter pylori; antimicrobial activity; plant extracts; acetone; hexane; MIC
Copyright: Creative Commons Attribution CC.
This license lets others distribute, remix, tweak, and build upon your work, even commercially, as long as they credit you for the original creation. This is the most accommodating of licenses offered. Recommended for maximum dissemination and use of licensed materials. View License Deed | View Legal Code Authors can also self-archive their manuscripts immediately and enable public access from their institution's repository. This is the version that has been accepted for publication and which typically includes author-incorporated changes suggested during submission, peer review and in editor-author communications.