The effect of aqueous stem bark extract of Erythrina mildbraedii on acetaminophen induced nephrotoxicity in rats
This study was carried out to determine the curative effect of aqueous stem bark extract of Erythrina mildbraedii in rats induced with nephrotoxicity using 800mg/kg Acetaminophen. Acetaminophen administration resulted in significant increase in the serum level of urea, creatinine, Na+, K+, Cl- and a significant decrease in the level of HCO3 - . Administration of different doses (50, 100, & 150mg/kg) of aqueous stem bark extract of Erythrina mildbraedii ameliorated the effect of Acetaminophen indicated by a significant decrease in the level of urea, creatinine, Na+, K+ , Cl- and an increase in the level of HCO3 - when compared to control rats. The histopathology showed a restoration of the renal architectures after administration of the aqueous stem bark extract.
Keywords: Acetaminophen, Erythrina mildbraedii, nephrotoxicity, aqueous extract.