Seroprevalence of human parainfluenza virus type 2 infection among children (1-5years) in Zaria, Kaduna state, Nnigeria

  • J Sale
  • A Ahmad
  • H Idris
  • A Aliyu
  • L Rogo
Keywords: Seroprevalence, Human Parainfuenza virus type 2, infection, respiratory tract infection, ELISA.

Abstract

Serological survey was carried out to determine the level of Human Parainfluenza virus type 2 (HPIV-2) IgG antibodies in children aged 1-5 years. Blood samples were collected from 379 children who met the selection criteria in selected hospitals in Zaria. Serum IgG antibody level for Human Parainfluenza virus type 2 was measured using commercial ELISA Kits obtained from VIRION-SERION ELISA Classic GmbH Germany. Of the total number of 379 samples, 176 (46.4%) were seropositive for parainfluenza virus type 2 antibody. There is statistical significance between age and seropositivity. Highest seropositivity (69.0%) was seen in the sera of those in age group 4- 5 yearss and lowest seropositivity (23.2%) in age group 0 – 1 year (X2 = 38.734; P.value <0.05). There was male predominance [91 (47.9%)] over females [85 (45%)] but the difference was not statistically significant (X2 = 0.325; P>0.05). There was no association between the presence of cough and catarrh/running nose with seropositivity (P >0.05). The results also showed that there was no association between the presence of sickle cell disease and parental smoking with seropositivity (P >0.05). Preventive programs against HPIV – 2 infection should be promoted especially in younger children and research why reinfection occurs even in the presence of neutralizing antibodies should be undertaken.
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eISSN: 2006-6996
print ISSN: 2006-6996