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The calls for repatriation and restitution of African objects and human remains in unlawful Euroamerican custody are gaining global momentum. This paper examines how bioarchaeological analyses are done on legitimately excavated or acquired human remains. Such studies are assessed in tandem with the negative eugenicist practices associated with the looted African human remains that were studied in Europe and America during the periods of slavery and colonization in Africa. It further examines the issues surrounding the repatriation of human remains and discusses the implications of this practice on the ethics and cultural rights of societies in Africa. Excavated human skeletal remains from Begho are examined within their cultural
context as a Ghanaian case study. By exploring these issues, we are of the view that the complexities in the nature of acquisition and return of human remains requires a holistic comprehension from multiple points of view rather than from a single subjective perspective. Such multiple approaches must include the need for adequate provenance and bioarchaeological research to bear on the contexts and practices associated with the anthropology of death in the societies of origin.