The Correlation between Thyroid Hormone Levels and the Kidney Disease Progression Risk in Patients with Type 2 Diabetes Mellitus

Abstract

Background: Thyroid hormone (TH) influences renal tubular function as well as the renin-angiotensin system.

Objective: The goal of this research was to evaluate the link between TH levels and the risk of renal disease development in patients with type 2 diabetes mellitus (T2DM).

Subjects and methods: This trail was carried out on 80 T2DM patients aged from 18 to 70 years old, both sexes, 20 normal healthy  volunteers as controls age- and sex-matched. All patients were subjected to history taking, complete clinical examination, routine  laboratory, and specific investigations (Renal function tests, estimated glomerular filtration rate (eGFR), albumin/creatinine ratio, lipid  profile, HBA1c, and thyroid function tests [Thyroid-stimulating hormone (TSH), free Tri-iodothyronine (FT3) and free thyroxine (FT4) levels  in serum]. 

Results: According to TSH, at a cut-off value of 1.015, the area under the curve was 0.950, the sensitivity was 100%, the  specificity was 80%, the PPV was 95.24%, and the NPV was 100%. Regarding FT3, at a cut-off value of 1.95, the area under the curve was  0.684, the sensitivity was 95%, the specificity was 78.8%, the PPV was 52.78% and the NPV was 98.44%. According to FT4, at a cut-off value  of 0.75, the area under the curve was 0.699, the sensitivity was 100%, the specificity was 82.5%, the PPV was 58.82%, and the NPV was  100%. 

Conclusions: Albumin/creatinine ratio, eGFR, HBA1c, TSH, and FT4 were significantly associated with the kidney disease  progression risk in patients with T2DM.