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As COVID-19 becomes fast spread, safe disposal of infectious and hazardous COVID-19 waste that has mixed with municipal waste is now becoming a major environmental challenge. In many cities in Nigeria, such wastes are often disposed of in landfills or incinerated openly. Though, significant attention has been paid to policy and management of COVID-19 in the health sector, little has been done in managing COVID-19 waste. Effective handling and disposal techniques of these wastes must be harnessed in sustaining the environment and curbing the spread of this disease. This paper is aimed at evaluating the two major precautionary measures taken against the spread of COVID-19; face covering and hand sanitizer, their chemical composition, use, disposal and impacts of their improper disposal on the environment. Common medical and disposable face masks are made of non-biodegradable plastic materials containing toxic additives that are carcinogenic, mutagenic and contribute significantly to climate change. Prolong or misuse of commonly used hand sanitizers can cause oral and dermal toxicity especially in children. Safer, economical and reusable materials to replace hitherto toxic materials used in curbing the spread COVID-19 should be made available. Aside from frequent washing of hands with soap and water, this paper recommends that attention should also be focused on public awareness on proper handling and disposal of all waste. Hospitals and municipal waste management should adopt the art of autoclaving before incineration of waste.